Molecular Formula: C5H14N4H2SO4
Molecular Weight: 228.27
Synonyms: N-(4-Aminobutyl) Guanidine Sulfate; N-(4-Aminobutyl)guanidine sulfate salt
Appearance: white to off-white powder
Solubility: Soluble in water
What is Agmatine sulfate?
Agmatine is a metabolic byproduct, or a breakdown of arginine through a process called decarboxylation. Agmatine is basically Arginine with the carboxylic acid end removed. Agmatine produces the byproducts Guanidino-butyladehyde and the polyamines putruscene, spermine, and spermidine which are involved in cell growth. Agmatine sulfate is the sulfate preparation of Agmatine, the decarboxylated form of L-arginine and an endogenous metabolic product highly conserved across life forms
Where does Agmatine come from?
Agmatine is produced in the body from the action of a particular enzyme which transforms L-Arginine to Agmatine. However, because the activity of that enzyme is rather low, we get a good majority from four other main sources, such as enerally meats, fish and shellfish contain high levels of Agmatine. It is also present in fairly high amounts in processed, fermented foods such as beer and sake.
Agmatine sulfate VS L-Arginine
agmatine sulfate does many of the same things that arginine should do, but it seems to be much more effective. Because Agmatine is already the metabolite of arginine and does not require further biochemical reactions, it actually works better than arginine and provides an increased effect on mood and focus. Fitness experts claim that agmatine sulfate will actually do a better job than arginine because the agmatine, as pointed out earlier, is a byproduct of arginine. Agmatine has already been put through so many tests and studies. All of them revealed that there are no side effects when using agmatine sulfate, nor any reported adverse side effect that may have affected any user of agmatine sulfate. Most popularly known for improving the body’s nitric oxide (NO) production, Agmatine sulfate promotes better nutrient transport, improved nutrient partitioning (meaning more calories are pumped into the muscle tissues and NOT stored as fat), and a healthier blood flow.
How does Agmatine Sulfate Work
The body produces agmatine by breaking down arginine. After agmatine is produced by the brain, it is stored in the synamptic vesicles and released during depolarization. Agmatine stimulates some nitric oxide synthase enzymes but it also inhibits its other forms. But one thing is for sure: agmatine has been proven to enhance the production of the growth hormone (GH), pituitary hormone, and luteinizing hormone (LH).
These hormones are necessary for muscle building. Many fitness experts and nutritionists say that agmatine sulfate is the best form or arginine supplement. Although it is available in the body, it is not distributed evenly. Agmatine traces largely accumulate in the stomach, small intestines, and aorta. To fully see the effects of agmatine sulfate on the body, research has it that it has to be taken from an external source.
Benefits of taking agmatine sulfate
Agmatine acts as a neurotransmitter and neuromodulator with a vast array of actions in the body. Agmatine sulfate has many benefits to the bodybuilder or athlete. The benefits of agmatine sulfate include enhanced muscle pumps, better nutrient partitioning (more calories are shuttled towards muscle tissue and less are stored as fat), and increased production of luteinizing hormone and growth hormone. The key benefits of taking agmatine sulfate are summarized as below:
- boost muscle pumps
Agmatine sulfate appears to boost muscle pumps in a couple different ways. First, agmatine sulfate may improve nutrient partitioning, leading to more muscle glycogen (carbohydrates stored in muscle tissue) stored and consequently more water retained in the muscle. This can lead to a full look to the muscle and increase muscle pumps. Second, agmatine sulfate also appears to increase nitric oxide production by acting as a competitive inhibitor of the enzyme nitric oxide synthase. The nutrient partitioning effects of agmatine may be due to its possible ability to increase the insulin response to carbohydrates, and it may also have something to do with the increased blood flow to the muscle experienced with increased nitric oxide production. Agmatine sulfate may play a role in the hypothalamic control of luteinizing hormone and growth hormone release, leading to increased levels of these hormones. Agmatine sulfate makes the muscle look full and healthy because it retains the water in the muscle cells. It increases the storage of muscle glycogen so that water stays inside the muscles. Thats why people taking these supplements experience increased pumps and bigger and fuller muscles.
- Increase nitric oxide production
The nutrient partitioning effects of agmatine may be due to its possible ability to increase the insulin response to carbohydrates, and it may also have something to do with the increased blood flow to the muscle experienced with increased nitric oxide production.
- Nootropic Effect
Agmatine sulfate may help those looking to achieve a mental edge, whether it is in the gym or in day to day life. It can also help support a healthy mood and has anti-anxiety and antidepressant properties. Agmatine may stack very well with other Nootropics,
- Stimulation of LH & GH Levels
In addition to the obvious appealing effect on overall body composition, the stimulation of GH and LH levels can also be beneficial for helping maintain a healthy lifestyle as we age. This stimulation of pituitary hormones may also lead to stimulation of other hormones such as IGF-1.
Agmatine is a pain fighter. This can be beneficial to the athlete in two ways: It can potentiate the effects of analgesics used during recuperation from injury; It has the potential to aid post-workout recovery.
- lose fat
Since agmatine can help boot muscle mass pump, increase production of Lean Muscle, thus resulting in more fat loss
Side Effects of Agmatine sulfate
Thankfully, Agmatine is relatively safe to use even at high doses and seems to have very low toxicity in cells. In the first clinical trial of Agmatine, there were few side effects however a very small percentage of people experienced mild-moderate diarrhoea and mild nausea.
Dosage of agmatine sulfate
Dosages of 1.5- 3.5 grams per day of Agmatine Sulfate have been shown to be safe in humans, though 3.5 grams caused mild diarrhea and nausea. The generally agreed upon dosing recommendation for Agmatine for physique-related benefits is 1,000mg first thing in the morning on an empty stomach.