What is Cissus Quadrangularis extract?
I bet that you may be the first time to hear about Cissus Quadrangularis, or at least you do not know much about it. So a general introduction is made here.
Cissus quadrangularis, belonging to the grape family, is an herb with an ancient history of use in refined and effective herbal medicine traditions, and has long been hailed as an especially powerful natural treatment for a variety of indications. In modern times, Cissus quadrangularis has become somewhat obscure but is gaining popularity among many medical practitioners and self-treating athletes for its restorative properties and other impressive uses. In traditional preparations, parts of the Cissus plants have been mashed, roasted, or made into a juice, pulp, or outright cooked concoction prior to application, but the majority of modern Cissus users are likely to experience the plant in the form of a capsule or powder. As the range of applications for this herb are quite variable, user experiences are diverse, yet the overwhelming consensus suggests that Cissus can be a remarkable alternative to Western medicines and a true blessing in terms of both potency and ability.
How does Cissus Quadrangularis extract work?
Cissus Quadrangularis has shown to prevent oxidative damage of DNA by reducing DNA fragmentation, indicating its block on cell death. Ulcer protection in Cissus quadrangularis-treated rats was confirmed by histoarchitecture, which was comprised of reduced size of ulcer crater and restoration of mucosal epithelium. Thus, reduced neutrophil infiltration, anti-apoptotic and antioxidant action have a pivotal role in the gastroprotective effect of Cissus quadrangularis. Previous research findings suggest that the gastroprotective activity of Cissus quadrangularis could be mediated possibly through its antioxidant effect as well as by the attenuation of the oxidative mechanism and neutrophil infiltration. Cissus quadrangularis may protect the gastric mucosa against ulceration by preventing gastric secretions.
For weight loss, researchers suggest that a formulation of Cissus quadrangularis might interact in a manner similar to statins, fibrates, probucol, nicotinic acid or cholesterol absorption inhibitors. Inhibition of the oxidation of LDL and the antithrombotic activity both aid in lowering total cholesterol/LDL-cholesterol and increasing HDL-cholesterol levels. Also, the phytochemical constituents in Cissus quadrangularis may have activity similar to other plant sterols. The molecular structure of phytotosterols, for example, is practically identical to that of cholesterol.
The active ingredient in Cissus Quadrangularis is Ketosterone. Ketosterone act as antagonists to the glucocorticoid receptor and promote good bone health, shows anabolic steroid properties for healing of fracture, increases intramuscular creatinine levels, blocks the muscle damaging effect of cortisol and leads to the formation of new muscles, shows significant inhibition in DPPH free radical formation, superoxide radical production and lipid peroxide production in erythrocytes, shows sedative effect on central nervous system, protects gastric mucosa against ulceration by its antisecretory and cytoprotective property, mobilizes fibroblast and chondroblasts to an injured tissue and enhances regeneration.
Benefits of taking Cissus Quadrangularis supplements
Cissus Quadrangularis is a plant related to grapes and has been used as an herbal remedy in India and other asian countries for hundreds of years. Cissus extract helps supporttendon, bone and muscle health. Cissus also provides anti-oxidant benefits and may support fat loss, weight management, and lean muscle. Key benefits are summarized as below:
Cissus Quadrangularis Benefits for Bone Healing as a jonit health ingredient
One of the best known benefits of Cissus quadrangularis is its ability to speed up the heeling of broken bones. It has been hypothesised that this works through the ability of Cissus quadrangularis to increase the metabolism and uptake of calcium, which is vital in the process of bone heeling. A study in dogs has shown that treatment with Cissus quadrangularis resulted in the complete healing of broken bones in 21 days, whereas those receiving a placebo were still unhealed at the same time. This effect has also been shown in rats, during which treated animals were observed to have a 50% increase in bone healing time. Undoubtedly, if you have sustained a fracture, your training will be severely affected. However Supplementing with Cissus quadrangularis may help to speed up your recovery. Cissus quadrangularis is popular among weight lifters because of thoughts that it might help arthritis.
Cissus Quadrangularis Benefits for Fat Loss
When combined with other fat burning ingredients such as green tea and chromium, it was observed that those receiving Cissus quadrangularis experienced an increase of 187% weight loss over those receiving the placebo, without dieting. This effect was greater for those who also commenced dieting. These authors attributed this weight loss to the ability for Cissus quadrangularis to act as a fat blocker and increase feelings of fullness. This shows that Cissus quadrangularis shows promise for use as a weight loss aid.
Cissus Quadrangularis Benefits for Lean Gains
Because of the effects of Cissus quadrangularis on bone healing, some authors have stated that it has anabolic properties and antiglucocorticoid effects. Combined, this means that muscle tissue is better preserved during times of physical and mental stress. Therefore, supplementing with Devil’s Backbone during training may help improve lean gains.
Dosage for Cissus Quadrangularis extract
The appropriate dose of Cissus quadrangularis extract depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of serving for Cissus quadrangularis. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Cissus quadrangularis extract has been shown to be effective in aiding weight loss when consumed at 514 mg twice a day before meals. This is therefore the recommended dosage and ingredient timing.
Cissus Quadrangularis Safety and Side Effects
Animal toxicological studies show that no signs of toxicity or side effects were observed in rats fed up to 2500 mg Cissus quadrangularis extract/kg body weight/day for 90 days. This is the equivalent of 200 g for an 80 kg man. Furthermore, human subjects did not report any side effects from the use of Cissus quadrangularis. It can therefore be concluded that the use of Cissus quadrangularis is safe.