What is Dong Quai (Angelica Sinensis)(Root) extract?
Dong Quai,known as Chinese Angelica, is a Chinese Herb of the Umbelliferae plant family.Before I wrote this article, I am not sure which names to act as the title since there are so may names for Dong Quai. As a Chinese, in domestic market, we use Dang Gui root instead. After searching google keyword tools, we found Dong Quai is the most popular for angelica sisnensis, while angelica sinsnensis is the latin name for it.
Dong quai comes in tablet, liquid extract, and raw root forms. In Chinese medicine, dong quai is often boiled or soaked in wine. The root is removed and the liquid is taken orally. Dong Quai is also known as Chinese Angelica and is primarily known for it’s uses in treating women’s problems including lack of sexual desire, the symptoms of menopause, cramps and PMS. It aids in increasing the effects of hormones in both men and women and is widely used as an aphrodisiac. Dong Quai is particularly useful in helping to end hot flashes and menstrual cramps. It is also used as a liver tonic and in treating sciatica and shingles. It is one of the most widely consumed herbs in China, used as frequently as ginseng and licorice. Dong quai has been used by the Chinese for more than two thousand years, as a strengthener of the heart, lung, spleen, liver and kidney meridians and as a tonic for the blood. It is traditionally characterized as a warm atmospheric energy that promotes blood circulation.
History of Dong Quai (Angelica Sinensis) extract
Dong Quai is the dried and sliced root of Chinese Angelica, a sturdy perennial plant that is native to China and Japan, and when cultivated, may reach a height of up to six feet, bearing bright green leaves and clusters of white flowers. Both the Chinese species(Angelica sinensis) and Japanese species (Angelica acutiloba) have have very similar therapeutic effects, although each country claims to produce the superior Dong Quai. In Asia, the plant has been cultivated for thousands of years for medicinal purposes and was first recorded in 588 B.C., for the treatment of painful menstruation. Often referred to as the Female Ginseng, it has been used to treat a wide variety of disorders, particularly «female» disorders, and in the Orient, Dong Quai is second only in reputation and sales to ginseng and licorice root. Chinese and Japanese herbalists have also used Dong Quai for the prevention and treatment of allergic symptoms in individuals who are sensitive to a variety of substances, such as pollen, dust, animal dander, foods, etc. Chemical constituents of Dong Quai include coumarins, essential oils, vitamins B-1, B-2, B-5 and vitamin C, beta-carotene, acids, calcium, iron, magnesium, manganese, zinc, phosphorus, potassium selenium, flavonoids and phytoestrogens (characterized by both high and low estrogen levels, which may account for much of the plant’s use to regulate competing actions).
chemical constituents of dong quai (Angelica Sinensis) extract
Dong quai contains essential oil (0.4-0.7%) consisting of 45% ligustilide, n-butylphthalide, cadinene, carvacrol, safrole and isosafrol. The root also contains sucrose (40%) and various lactonesand vitamins, together with phytosterols, ferulic acid and coumarins, including osthole, psoralen and bergapten. Ferulic acid and ligustilide are considered to be the main active components and it has been suggested that assessment of total ferulic acid content provides a good measure of herbal quality.The active constituents in dong quai are a group of coumarin derivatives including oxypeucedanin, osthole, imperatorin, psoralen, and bergaptin.
How does Dong Quai (Angelica Sinensis) work?
The applicable part of dong quai is the root. Dong quai root has several active constituents. Some of these include ferulic acid, ligusticide, angelicide, brefeldin A, butylphthalide, nicotinic acid, and succinic acid. Dong quai root contains a variety of other constituents including n-valerophenone-O-carboxylic acid, uracil, adenine, carvacrol, safrole, isosafrole, sesquiterpenes, n-dodecanol, n-tetradecanol, palmitic acid, angelic acid, myristic acid, and others.
The dong quai root also contains several vitamins and minerals including vitamin A, carotenoids, vitamin E, vitamin C, vitamin B12, biotin, folic acid, calcium, magnesium, and phytosterols such as beta-sitosterol (15109). It also contains 0.4% to 0.7% volatile oil.
Dong quai also contains several coumarin constituents, however, there has been some debate about which coumarins are present in dong quai root. Some coumarins reported to be present in the root include angelol, angelicone, osthol, psoralen, oxypeucedanin, and bergapten. Some coumarins can act as vasodilators and antispasmodics. Osthol appears to inhibit platelet aggregation and smooth muscle contraction, and cause hypotension. Psoralen and bergapten are photosensitizing and can cause severe photodermatitis. Bergapten and other dong quai constituents, such as safrole and isosafrole, are carcinogenic.
Therapeutic pharmacologic activity is most often attributed to the ferulic acid and ligusticide constituents. Ferulic acid and ligusticide are sometimes used as marker compounds to assess dong quai root quality. The amount of these constituents in dong quai root can vary significantly from region to region.
Ferulic acid content usually ranges from 0.211-1.43 mg/gram of dong quai root. Ferulic acid is thought to have a wide variety of activities including antioxidant, anti-inflammatory, immunostimulant, antiarrhythmic and antiplatelet effects.
Ligusticide content ranges from about 4-14 mg/gram of dong quai root. The ligusticide constituent is thought to have antispasmodic and antiasthmatic effects. Dong quai also contains a low molecular weight polysaccharide that shows anti-tumor activity in animals.
Some research suggests that dong quai root does not have estrogenic effects and therefore is not a phytoestrogen. However, other research suggests that it does have estrogenic effects. A dong quai extract competitively inhibits estradiol binding to estrogen receptors and induces transcription activity in estrogen-responsive cells. The ferulic acid constituent seems to have estrogenic activity. Ferulic acid stimulates proliferation of estrogen-receptor positive breast cancer cells in vitro. It also appears to up-regulate transcription of HER2 oncogene and ESR1 gene. A water-soluble extract of dong quai stimulates proliferation of both estrogen-receptor positive and negative breast cancer cells in vitro. The effect on estrogen-receptor positive cells appears to involve estrogen agonist activity. The effect on estrogen-receptor negative cells is independent of estrogen.
Preliminary research suggests dong quai might protect against ischemia-reperfusion injury.
Research in animal models also suggests that dong quai might help protect against endotoxemia and experimental sepsis. Dong qui might help reduce accumulation of inflammatory cytokines.
A multi-ingredient preparation containing dong quai is thought to work in premature ejaculation by increasing the penile vibratory threshold and reducing the amplitude of penile somatosensory evoked potentials.
Benefits of Dong Quai (Angelica Sinensis) extract
Dong Quai is a traditional Chinese herbal remedy that is growing more popular here in the Western world. Why it’s gaining popularity has much to do with the tremendous benefits for both men and women. In fact, dong quai has been touted as a cure for infertility, hot flashes and maybe even cancer. The key benefits are summarized as below:
- Improves Female Fertility
Just an era ago infertility was uncommon, but these days we see it quite often. In many cases all that one needs is to switch their diet to an antifungal diet and to start taking this herb, and yet people still frequently seek the aid of costly fertility experts and undergo painful methods.
- Boosts male fertility.
Ferulic acid, an antioxidant found in dong quai, has been shown to improve sperm quality.
3.Balances estrogen levels.
Dong quai is the premier «gynecological regulator.» It has the ability to reduce your estrogen levels if they are too high and can increase them if they are too low.
4.Excellent blood tonic.
Master herbalist, Ron Teeguarden, attributes the blood toning and nourishing effects of dong quai to its amazing vitamin and mineral content. Dong quai contains vitamin B 12, folic acid, folinic acid, nicotinic acid, and biotin.
Dong quai is helpful after any injury or surgery to replenish your red blood cells and increase blood volume. It’s included in nearly all Chinese herbal blood-building formulas.
5.benefits for women’s health
Dong quai, derived from the root of the Chinese perennial Angelica sinensis, ranks just below ginseng as the most popular herb in China and Japan. It has often been referred to as the «female ginseng,» popular among women for centuries as a «blood tonic» and used to promote a healthy menstrual cycle and to ease normal menstrual discomfort.
Currently, one of the most popular uses for angelica sinensis is as a treatment during and aftermenopause. It has been celebrated by herbalists for containing phytoestrogens, which may help replace missing estrogen and make less noticeable some of the symptoms of menopause. As previously mentioned, these claims are not verified by the traditional medical community and it is unclear that Dong Quai is of any use.
Side effects of Dong Quai (Angelica Sinensis) extract
Dong quai is generally considered to be quite safe when used properly. Dong quai is not recommended for pregnant or breast-feeding women. Because the root contains chemicals called psoralens, dong quai may cause some fair-skinned people to become more sensitive to sunlight. Dong quai should not be used by those who have chronic diarrhea or abdominal bloating. The essential oil of dong quai contains a small amount of cancer-causing substances, so driking directly drinking is not recommended. Men with prostate cancer and women with endometriosis, breast cancer, or cancers of the uterus or ovaries should not take dong quai. Dong quai may increase the anti-clotting effects of prescription anticoagulants and antiplatelet agents, aspirin, and other herbal products.
Dosage of Dong Quai (Angelica Sinensis) extract
Dong quai is used in numerous herbal combinations, and various doses have been used both traditionally and in research in China. Because of this variation and lack of high-quality studies, no specific recommendations can be made. Safety and effectiveness are not established for most herbal combinations, and the amounts of Dong quai present from batch to batch may vary.
Powdered or dried root/root slices, fluid extracts, tinctures, decoctions, and dried leaf preparations of Dong quai are available to be taken orally. Topical preparations are available to be applied to the skin. Safety of intravenous use is not established, although it has been reported in research.
Where to buy 100% natural Dong Quai (Angelica Sinensis) extract?
Nutragreen Biotechnology Co., Ltd, a brand of Shanghai Lvshang Biotech Co., Ltd, is a GMP compliant and FDA registered manufacturer and supplier of raw materials of plant extracts, botanicals, herbs, especially Tradtional Chinese herbs. Dong Quai(Angelica Sinensis) extract is one of our most competitive ingredients with various specifications and stocks available all year round. You may leave a message below for more detailed information.