What is Maitake Mushroom extract?
Maitake, also known as hen of the woods, is a large mushroom native to Japan, North America and Europe. Often found growing in clumps around the base of oak trees, maitake can reach a weight of 50 pounds. Scientific study shows the extract of this highly prized edible mushroom may have potential benefits for cholesterol and blood sugar levels, immune function and cancer treatment and prevention.
Chemical constituents of Maitake Mushroom extract
Maitake is rich in minerals (such as potassium, calcium, and magnesium), various vitamins (B2, D2 and niacin), fibers and amino acids. One active constituent in Maitake for enhancing the immune activity was identified in the late 1980s as a protein-bound beta-glucan compound.
the main active ingredient of Polysaccharides.components in glucan is given priority to, with beta — (1-6) branch of beta — (1 — > 3) glucan as the basic structure, containing a small amount of mannose and xylose.
Benefits of taking Maitake Mushroom extract supplements:
Maitake polysaccharides have the function of anti-cancer, anti-hypertension, depress blood sugar, anti-fat, anti-hepatitis, according to some America professional hospital prove, during chemotherapy, use maitake polysaccharides to restrain cancer cell will be better than only use chemotherapy. Japanese professor use maitake polysaccharides to anti cancer, the experiment prove than maitake can restrain 86.5%, 32% higher than shiitake polysaccharides.
America national cancer institute proved in 1992 than maitake extract have the function of anti-AIDS.
Preliminary evidence shows that maitake may help lower cholesterol levels, notes CoxHealth Medical Center. A study on laboratory animals published in the October 2011 issue of the «Journal of Agriculture and Food Chemistry» found that four weeks of supplementation with maitake mushroom extract lowered liver cholesterol levels. Researchers concluded that maitake exerted its effects at the genetic level by increasing activity of genes in the liver that promote lipid transport. By contrast, Hypsizigus marmoreus, or beech mushroom, another mushroom tested in the study, did not show cholesterol-lowering effects.
Maitake may help manage blood sugar levels and prevent diabetes, according to a study published in the April 2007 issue of the «Journal of Pharmacy and Pharmacology.» A polysaccharide molecule in maitake, called MT-alpha-glucan, decreased fasting blood sugar and insulin levels and increased levels of glycogen, a short-term storage form of glucose, in the liver. Maitake also increased the ability of insulin to bind to liver cells and improved pancreatic function. Researchers concluded that maitake may be useful for prevention and management of diabetes by decreasing insulin resistance.
Immune benefits of maitake extract include modulation of cytokines, molecules produced by white blood cells that activate the immune response, according to the University of Wisconsin Botany Department. Maitake exerts its effects by binding to the cell membranes of white blood cells known as macrophages and either activating or inhibiting release of cytokines. A study published in the Summer 2004 issue of the «Journal of Medicinal Food» found that D-fraction, a polysaccharide extract of maitake, activated several types of immune cells and molecules, including T-helper cells, macrophages and interleukins. Researchers concluded that maitake may offer immune benefits that help protect against infection.
Maitake D-fraction may inhibit cancer development and spread and also make chemotherapy drugs more effective, according to Dr. Shari Lieberman, author of the book «Maitake Mushroom and D-Fraction.» A study published in the June 2011 issue of the «Journal of Medicinal Food» found that maitake D-fraction promotes apoptosis — programmed cell death — in breast cancer cells. Maitake extract interfered with energy production in cancer cells, a discovery which, researchers note, will help scientists target potential cancer prevention and treatment approaches.
Early studies in the laboratory as well as in humans suggest that beta-glucan extracts from maitake may increase the body’s ability to fight cancer.
A 1997 study published in the Annals of the New York Academy of Science found that maitake D-fraction was able to enhance the immune system and inhibit the spread of tumors in mice implanted with breast cancer. In a 1995 report published in the same journal, researchers concluded that maitake D-fraction was able to activate the immune systems of mice that had been injected with liver cancer cells. The extract seemed to prevent the spread of tumors to the liver and prevent the development of cancer in normal cells.
Side effects and safety of Maitake Mushroom extract
Even in large doses, maitake have showed no toxicity. Although it is extremely rare, however, the entire taking maitake may cause mild stomach or intestinal disturbance. There is no any drug interaction and maitake messages.
Dosage of Maitake Mushroom extract supplement:
Maitake can be used as food or tea, also can make it contain maitake polysaccharide capsule or tablet. Half is recommended to take 3-7 grams of maitake the original medicinal materials, the equivalent of 300-700 mg of polysaccharide.