Levodopa was the first breakthrough in the treatment of Parkinson’s Disease. Its development was based on the discovery that people with Parkinson’s Disease experience a severe loss of a substance in the brain — a chemical messenger — called dopamine. Since its introduction in the late 1960’s, when it was heralded as a ‘miracle’ medication, Levodopa has remained the cornerstone of Parkinson’s Disease therapy. More than 30 years after its discovery, Levodopa is still the most widely used treatment for Parkinson’s Disease, and almost all patients require Levodopa at some point during the course of their illness.
During the first few years of Levodopa clinical use, large amounts of Levodopa were needed to be effective. These large doses were associated with side-effects such as nausea and vomiting and were due to the rapid breakdown of Levodopa in the body by enzymes. One of the main enzymes involved in this breakdown of Levodopa is peripheral dopa-decarboxylase (DDC). It was quickly realised that by inhibiting this enzyme using a DDC inhibitor, it was possible to reduce the Levodopa dose by 70%, thereby reducing the severity of side-effects. This combination is so effective that, today, Levodopa is almost always given in the same tablet with a DDC inhibitor, either carbidopa or benserazide. However, when DDC is inhibited another enzyme, catechol-O-methyl transferase (COMT), takes over the breakdown of Levodopa. Consequently, COMT inhibitors were recently developed as a way of further improving the delivery of Levodopa to the brain.
[CAS NO.]: 59-92-7
[Molecular Weight]: 197.19
1. Treat parkinsonism and Pakinsonism syndrome, hepatic coma,hub functions to improve the patient awake, symptom improvement;
2. Promote sleep,improve immune system;
3. Weight loss
4. Increase bone density and reversal of osteoporosis,increase muscle strength,enhance libido and sexual performance.
1. Applied in pharmaceutical field;
2. Applied in health food field.
Packing & Storage：
Pack in paper-drums and two plastic-bags inside. Net Weight: 25kgs/paper-drum.
1kg-5kgs plastic bag inside with aluminum foil bag outside. Net Weight: 20kgs-25kgs/paper-drum.
Store in a well-closed container away from moisture and light.
2 years if sealed and store away from direct sun light.
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