What is Rutin?
Rutin is also known as rutoside, quercetin-3-rutinoside and sophorin. It is a compound that is naturally produced in certain plants.
Rutin is a yellow crystalline flavonol glycoside (C27H30O16) that occurs in various plants (rue, tobacco, buckwheat, etc.). Upon hydrolysis (a chemical reaction that uses water to break down a compound), rutin yields quercetin and rutinose.
Molecular Formula : C27H30O16.3(H2O)
Molecular Weight : 664.57
CAS Registry Number: 153-18-4
EINECS : 205-814-1
Benefits of taking Rutin supplements:
Rutin is used in many countries as a vasoprotectant and is an ingredient in numerous multivitamin preparations and herbal remedies. The rutosides are naturally occurring flavonoids that have documented effects on capillary permeability and edema (swelling) and have been used for the treatment of disorders of the venous and microcirculatory systems.
There is some evidence for the use of rutin for chronic venous insufficiency, edema, hemorrhoids, microangiopathy (disease of small blood vessels), varicosis and venous disorders. There are a number of natural compounds that help to improve the structure of the vascular system including vitamin C and the amino acids lysine and proline. Researchers publishing in The Journal of Clinical Investigation describe the effect of a compound called rutin, commonly found in fruits and vegetables and sold over the counter as a dietary supplement that has been shown to inhibit the formation of blood clots in an animal model of thrombosis.
Rutin flavonoids prevent blood clots by inhibiting platelet aggregation
To conduct the study, researchers focused on a protein called disulfide isomerase (PDI) which is found in all cells. Past studies have shown that PDI is rapidly secreted from both platelets and endothelial cells during thrombosis when a clot forms in a blood vessel, and that inhibition of PDI could block thrombosis and prevent a fatal stroke or heart attack. The scientists therefore developed a wide-scale search for a natural agent capable of inhibiting the PDI protein and prevent vascular thrombosis.
Researchers identified quercetin-3-rutinoside (rutin), a bioflavonoid that is naturally found in many fruits, vegetables and teas including onions, apples, and citrus fruits. The scientists noted that «Rutin proved to be the most potently anti-thrombotic compound that we ever tested», as the flavonoid was shown to inhibit both platelet accumulation and fibrin generation during thrombus formation. Three to five daily servings of rutin from dietary sources or supplementing with 500 mg per day is shown to reduce platelet stickiness leading to blood clots and risk of early death from stroke and heart attack.
Hemorrhoids are caused from swollen veins in the anus. Rutin is used as a treatment for them.
Preliminary evidence suggests that o-(beta-hydroxyethyl) rutosides and trihydroxyethylrutosides may be safe and effective treatments for hemorrhoids. Studies investigating the effect of rutin in different populations, as well as efficacy on third or fourth degree hemorrhoids are warranted in future studies.
Some people bruise easily. Rutin is used to treat bruising of the skin.
In one clinical trial, O-(beta-hydroxyethyl)-rutoside offered benefit in terms of skin irritation to individuals with breast cancer undergoing radiation treatment.
Rutin also helps with the absorption of Vitamin C, which is beneficial to collagen production.
Being that rutin has antioxidants, it helps to kill free radicals which, in turn, boosts immunity.
Rutin can help improve circulation. One particular condition that this helps is varicose veins.
One well designed study suggests that O-[beta-hydroxyethyl]-rutosides may offer benefit in terms of schizophrenia.
Side effects and safety of Rutin
Rutins have been used effectively and safely in several clinical and equivalence trials. Numerous reports have reported no adverse side effects with rutin treatment. Laboratory findings were noted as unchanged. Few adverse effects have been reported, most of which were mild or transient. Rutin is possibly unsafe when taken in very high doses for long periods of time.
Dosage of Rutin supplement:
It is general 500 mg doses taken 1 to 2 times daily.