What is Salvia miltiorrhiza Powder Extract?
Salvia Militorrhizashen is a traditional asian herbal medication for circulatory ailments.
Danshen works through a few primary ingredients, which all work synergistically on various parameters of heart and circulatory health.
The traditional Chinese remedy Salvia miltiorrhiza, also known as «danshen», is one such plant that is attracting attention in the West as an overall excellent support for cardiovascular health. It contains several unique phytochemicals with cardioprotective and antioxidant properties, and has been widely used in Chinese medicine for numerous cardiovascular disorders.
In fact, according to one report, Salvia has «revolutionized the management of angina, heart attack and stroke in Chinese society.» The majority of research on Salvia has been on its heart protective properties, especially in cases of angina (a condition where inadequate oxygen is available to the heart muscle itself), heart attack and stroke.
Danshen (Salvia miltiorrhiza) is widely used in traditional Chinese medicine (TCM), often in combination with other herbs. It grows primarily in the hilly areas in the west and southwest provinces of China, with some also produced in the southeast part of China. Remedies containing danshen are used traditionally to treat a diversity of ailments, particularly cardiovascular disorders, such as atherosclerosis or blood clotting abnormalities. The ability of danshen to improve blood circulation has not been demonstrated in high-quality human trials. Constituents of the danshen root, particularly protocatechualdehyde and 3,4-dihydroxyphenyl-lactic acid, are believed to be responsible for its vascular effects.
Chemical constituents of Salvia miltiorrhiza Powder Extract
Major chemical constituents in salvia root can be divided into water-soluble and fat-soluble types. The fat-soluble type include tanshinones I, IIA-IIB, V-VI; cryptotanshinone, isotanshinones I-II, IIB; isocryptotanshinones I-III; hydroxytanshinone IIA, methyltanshinonate, danshenxinkuns A-D, etc. The water-soluble type include salvianolic acids A-G; rosmarinic acid, lithospermic acid, protocatechualdehyde, caffeic acid, and isoferulic acid, etc.
Benefits of taking Salvia miltiorrhiza Powder Extract
Salvia miltiorrhiza and heart
>Salvianolic acid A promotes the acceleration of neovascularisation in the ischemic rat myocardium and the functions of endothelial progenitor cells.
(Source-Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China. )
Salvia miltiorrhiza (SM, also known as DanShen) is one of the well-known widely-used Chinese herbal medicines in clinical, containing phenolic compounds and potent antioxidant properties. Salvianolic acid A (SAA)is the most potent component of SM.
AIM OF THE STUDY:
A modern experimental strategy for treating myocardial ischemia is to induce neovascularization of the heart by the use of «angiogens», mediators that induce the formation of blood vessels, or angiogenesis. Studies demonstrated that coronary collateral vessels protect ischemic myocardium after coronary obstruction; therefore we sought to examine whether SAA could stimulate myocardial angiogenesis.
MATERIALS AND METHODS:
Male Sprague-Dawley rats myocardial infarct (MI) induced by ligation of left anterior descending coronary artery (LAD), were randomly divided into five groups: sham-operated group; LAD occlusion + administration of physiological saline (vehicle treated group); LAD occlusion + administration of different concentrations of SAA (10, 5.0 and 2.5 mg/kg/d). Infarct size and capillary density in the infarct region were measured with a previous experimental method. Immunohistological analysis was performed to measure vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2) expressions. The secretion of matrix metalloproteinase type Ⅹ (MMP-9) was evaluated in serum of postischemic rats. We also performed the experiments of SAA on rat endothelial progenitor cells (EPCs) numbers and the capacity of migration and vasculargenesis.
SAA potentiated the ischemia-induced neovascularization after 1 week post-operation when compared to vehicle treated group. This effect could be attributed to an increased formation of VEGF, VEGFR-2, MMP-9 as well as the promotion of numbers and functions of EPCs.
These findings show that SAA has potent proangiogenic properties by promoting the expression of proangiogenic factors, and the functions of EPCs, indicating that SAA might contribute to the protective effect against coronary disease. Chemical compounds studied in this article salvianolic acid A (PubChem CID: 5281793).
>Aqueous extract of danshen (Salvia miltiorrhiza Bunge) protects ovariectomized rats fed with high-fat diet from endothelial dysfunction.
(Source-College of Light Industry and Food, South China University of Technology, Guangzhou, PR China.)
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in postmenopausal women. Danshen, the dried root of Salvia miltiorrhiza Bunge, has been used clinically in China to treat CVD and dyslipidemia in postmenopausal women, and its major active ingredients have been found to have an estrogenic effect. The aim of this study was to elucidate the underlying mechanism of danshen’s protective effects on vascular function in an ovariectomized (OVX) hyperlipidemic rat model.
Thirty-five 6-month-old female Sprague-Dawley rats were randomly divided into five groups: sham-operated rats with low-fat control diet + vehicle, sham-operated rats with high-fat diet (HFD) + vehicle, OVX rats with HFD + vehicle, OVX rats with HFD + 17β-estradiol (1 mg kg d, PO), and OVX rats with HFD + danshen aqueous extract (600 mg kg d, PO). After 12 weeks of treatment, gains in body weight and serum lipid profile levels in rats were measured and histological examination of livers was carried out. Vascular function was evaluated by measuring relaxation responses. Molecular mechanisms were also analyzed in isolated aorta.
Treatment with danshen aqueous extract reduced body weight gain, improved serum lipid profiles, and prevented formation of fatty liver induced by HFD and OVX. In addition, danshen could increase endothelial-dependent vasorelaxation and displayed vasoprotection in OVX rats fed with HFD, primarily by stimulating nitric oxide (NO) production, up-regulating the mRNA expression of endothelial NO synthase, and down-regulating the mRNA expression of tumor necrosis factor α, intercellular cell adhesion molecule-1, and vascular cell adhesion molecule-1 in the isolated aortas.
We conclude for the first time that danshen aqueous extract could protect OVX rats fed with HFD from endothelial dysfunction. Its effect may be related to its abilities to normalize serum lipid profiles and enhance NO availability in the vascular system. Our findings indicate that danshen aqueous extract could be a promising natural supplement for postmenopausal women for preventing CVD.
Salvia miltiorrhiza and liver
>Effect of Chinese herbal compound on liver fibrosis in rabbits with schistosomiasis by B-ultrasound.
(Source-Department of Ultrasonography, Military General Hospital of Beijing PLA, Beijing, China.
To explore the value of B-ultrasound on the evaluation of the effects of traditional Chinese medicine compound of Radix astragali, Salvia miltiorrhiza and Angelica sinensis, and TCM + praziquantel on liver fibrosis in rabbits with schistosomiasis.
The hepatic fibrosis model in rabbits with schistosomiasis was established. The experimental animals (24 rabbits) were randomly divided into four groups (group A, B, C and D, n=6). Group A (control group) was only treated by praziquantel; Group B was treated by mixture of Radix astragali and Salvia miltiorrhiza + praziquantel; Group C was treated by mixture of Radix astragali and Angelica sinensis + praziquantel; Group D was treated by mixture of Radix astragali, Salvia miltiorrhiza and Angelica sinensis + praziquantel. Then B-ultrasonogram was used to evaluate the effects.
Each group showed certain curative effect on liver fibrosis in rabbits with schistosomiasis. The efficacy of group B, C and D was better than group A, and that of group D was the best. The differences in long diameter, thickness diameter, transverse diameter and portal vein inner diameter of liver before and after treatment were statistically significant (P<0.05). The liver function indexes and liver fibrosis indexes were significantly improved after treatment (P<0.05).
The mixture of Radix astragali, Salvia miltiorrhiza and Angelica sinensis combined with Western medicine treatment can obviously improve the efficacy on liver fibrosis of schistosomiasis.
Salvia miltiorrhiza and cancer
Molecular evidence of cryptotanshinone for treatment and prevention of human cancer.
(Source-College of Pharmacy and Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, China. )
Cryptotanshinone is one of the major tanshinones isolated from the roots of the plant Salvia miltiorrhiza Bunge (Danshen). Danshen has been widely used in traditional Chinese medicine for treatment of a variety of diseases, including coronary artery disease, acute ischemic stroke, hyperlipidemia, chronic renal failure, chronic hepatitis, and Alzheimer’s disease, showing no serious adverse effects. Recent studies have shown that cryptotanshinone not only possesses the potential for treatment and prevention of the above-mentioned diseases, but also is a potent anticancer agent. Here we briefly summarize the physical and chemical properties and the pharmacokinetic profiles of cryptotanshinone, and then comprehensively review its anticancer activities as well as the underlying mechanisms.
>coronary artery disease,
>acute ischemic stroke
>chronic renal failure
Side effects and safety of Salvia miltiorrhiza Powder Extract
Danshen seems to be safe for most people. It can cause some side effects, including itching, upset stomach, and reduced appetite.
Not enough is known about the use of danshen during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Dosage of Salvia miltiorrhiza Powder Extract
Many Salvia miltiorrhiza Powder Extract 10:1 supplements recommend a dosage of around 1500 mg to 2000 mg.