What is Semen Pharbitidis Extract powder?
Qian Niu Zi is also known as Morning glory seeds. The bitter, cold and toxic herb has been used in TCM to treat edema, ascites, constipation, difficulty in urination, abundance of phlegm, cough, asthma, etc. as it eliminates Water and accumulations, expels worms and other parasites, etc., by enhancing the functions of lung, kidney and large intestine channels.( according to TCMWIKI)
Chemical constituents of Semen Pharbitidis Extract powder
General include Palmitic acid , Gibberellin A3, Gibberellin A20, 26, 27 and Glucoside, Pharbitic acid C, D and Pharbitin, Tiglic acid.
Benefits of taking Semen Pharbitidis Extract powder supplements:
Traditional Chinese Medicine
It can take effect of relaxing bowels with purgative or removing stagnation and resolving accumulation when being used in small dose. Because of the bitter and cold nature, it is suitable for constipation due to heat accumulation and can be combined with offensive purgatives like Da Huang. For food stagnancy, it can be combined with digestion-promoting and qi-moving herbs, such as Lai Fu Zi and Qing Pi. It can not only expel ascarid but pass parasites with purgative from the body, and it is often combined with antihelminthic, Bing Lang and Shi Jun Zi are the examples.
- Anthelmintic activity
In the search of a natural antiparasitic, in vivo anthelmintic activity of petroleum ether, chloroform, ethyl acetate, methanol, and aqueous extracts of Angelica pubescens roots (Radix angelicae pubescentis), Brucea javanica fruits (Fructus bruceae), Spatholobus suberectus stems (Caulis spatholobi), Aesculus chinensis Bge. seeds (Semen aesculi), and Pharbitis purpurea (L.) Voigt seeds (Semen pharbitidis) were tested against Dactylogyrus intermedius (Monogenea). Among the extracts tested, the methanolic and aqueous extracts of S. aesculi were observed to be more efficient than the other plant extracts with EC(50) and EC(90) values of 5.23 and 7.33 mg/L and 6.48 and 12.29 mg/L after 48 h, respectively, followed by methanolic extracts of Fructus bruceae, Radix angelicae pubescentis, Caulis spatholobi, and Semen pharbitidis with EC(50) 49.96, 57.45, 64.92, and 309.47 mg/L. The methanolic and aqueous extracts of S. aesculi exhibited potential results and can be exploited as a preferred natural antiparasitic for the control of D. intermedius.
- Functional dyspepsia
DA-9701 is a new botanical drug composed of the extracts of Corydalis tuber and Pharbitidis semen, and it is used as an oral therapy for the treatment of functional dyspepsia in Korea. DA-9701 and Corydalis tuber extract slightly inhibited UGT1A1-mediated etoposide glucuronidation, with 50% inhibitory concentration (IC(50)) values of 188 and 290 μg/mL, respectively. DA-9701 inhibited CYP2D6-catalyzed bufuralol 1′-hydroxylation with an inhibition constant (K(i)) value of 6.3 μg/mL in a noncompetitive manner. Corydalis tuber extract competitively inhibited CYP2D6-mediated bufuralol 1′-hydroxylation, with a K(i) value of 3.7 μg/mL, whereas Pharbitidis semen extract showed no inhibition.
- Anti-parasitic effects
In the study to isolate the active compounds responsible for the anthelmintic activity of methanol extract of Semen pharbitidis against Dactylogyrus intermedius in goldfish (Carassius auratus), indicated that according to in vivo anthelmintic assays, they were found to be 50% effective at the concentrations (EC(50)) of 5.3 and 1.4mgL(-1), respectively. The promising palmitic acid and pharnilatin A from S. pharbitidis were also subjected to acute toxicity tests for the evaluation of their safety to the host (goldfish). After 48h exposure, the mortalities of goldfish were recorded, and the established LC(50) values were 2.45- and 5.29-fold higher than the corresponding EC(50), demonstrating that pharnilatins A may have better application potential than palmitic acid.
Side effects and safety of Semen Pharbitidis Extract powder
- Do not use in cases spleen and qi deficiency
- The raw seed is toxic
- Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
Dosage of Semen Pharbitidis Extract powder supplement:
Consult your physician if you have any questions about the proper use of Semen Pharbitidis Extract powder supplements.