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Microcrystalline cellulose (MCC) is one of the most sought-after excipients in modern industry. If you're looking for high-quality, low-moisture cellulose powder to stabilize sensitive formulations, Grade 112 is the ideal choice.
In this description, we'll cover in detail what MCC is, its properties, and the purpose of this particular modification. The product is a purified, partially depolymerized alpha-cellulose derived from plant fiber. Microcrystalline Cellulose 112 differs from standard grades in its critically low moisture content (LOD < 1.5%), making it indispensable for working with hygroscopic active ingredients.
Technical Specifications (According to COA)
The data in the table are based on batch specifications and international standards (USP/EP/JP).
Characteristic
Value / Description
Product Name
Microcrystalline Cellulose 112 (MCC) 112)
English name
Microcrystalline Cellulose NF, Ph. Eur., JP, ChP, E460 (i)
Chemical Formula
(C6H10O5)n
CAS Number
9004-34-6
Appearance
White or almost white fine or granular powder
Packaging
20 kg / 25 kg bags (multilayer paper with PE liner)
EC (EINECS) number
232-674-9
HS code (customs code)
3912 90 90
Certification
Complies with NF, Ph. Eur., JP, ChP, E460 (i), FCC
Country of Origin
On Request
Melting Point
260-270°C (Charring)
Loss on Drying (LOD)
Max. 1.5%(Actual: ~0.5-1.2%)
Solvent Residues
Complies with requirements (CPMP/ICH/283/95)
Heavy Metals
Max. 10 ppm
Ash (Sulphated Ash)
Max. 0.05%
pH (1% Solution)
5.0 – 7.5
Solubility
Practically insoluble in water, acetone, ethanol
Density (bulk)
0.28 – 0.36 g/ml (varies by lot)
Storage Conditions
In a sealed container, in a dry place
Safety
Non-toxic, food additive E460
Certificate of Analysis Specification
| Characteristic | Acceptance Criteria | Batch Analysis Result |
| Identification A | IR spectrum complies | Complies |
| Identification B | Violet-blue color | Complies |
| Identification C | Max. 350 | Complies |
| pH | 5.0 - 7.0 | 5.9 |
| Loss on drying | Max. 1.5% | 0.5% |
| Bulk Density | 0.30 - 0.36 g/ml | 0.33 g/ml |
| Electrical Conductivity | Max. 75 µS/cm | 24 µS/cm |
| Particle size (laser diffraction) d10 | 20 - 50 µm | 33 µm |
| Particle size (laser diffraction) d50 | 90 - 150 µm | 130 µm |
| Particle size (laser diffraction) d90 | 190 - 300 µm | 236 µm |
| Particle size (air-sieve Analysis) > 250 µm | Max 8% | < 1% |
| Particle size (Air Sieve Analysis) > 75 µm | Min 45% | 61% |
| Particle size (Air Sieve Analysis) > 32 µm | Min 70% | 83% |
| Sulphated ash / residue after ignition | Max 0.05% | < 0.05% |
| Heavy Metals | Max 10 ppm | < 10 ppm |
| Arsenic | Max 0.0002% | Complies |
| Chlorides | Max 0.03% | Complies |
| Ether-Soluble Substances | Max 0.05% | Complies |
| Water-soluble substances | Max. 0.2% | Complies |
| Total aerobic microorganism count (TAMC) | 10 2 CFU/g | Complies |
| Total yeast and mold count (TYMC) | 20 CFU/g | Complies |
| E. coli, Pseudomonas aeruginosa, Staph. aureus | Absent in 1 g | Absent |
| Salmonella spec. | Absent in 10 g | Absent |
| Solubility | Completely soluble | Compliant |
| Starch | Negative | Compliant |
| TUP (Technically Unavoidable Particles) | Max. 9 / 600 cm2 | Complies |
Detailed Description. What is Microcrystalline Cellulose?
Many customers ask: What is microcrystalline cellulose and how does it differ from regular cellulose? It is a natural polymer that has undergone deep purification and acid hydrolysis to remove amorphous regions. The result is crystalline microcellulose—a chemically inert, safe powder that does not react with other components of the mixture.
Microcrystalline cellulose is a universal filler, binder, and leavening agent "all in one." Grade 112 has an increased particle size (approximately 100-130 µm), which ensures excellent flowability, similar to Grade 102, but with improved stability.
Why should you order MCC 112?
- Ultra-low moisture. While standard crystalline cellulose contains up to 5-7% water, Grade 112 contains less than 1.5%. This is critical for manufacturers of microcrystalline cellulose used in effervescent tablets and moisture-sensitive antibiotics.
- Direct compression.This grade of microcrystalline cellulose powder eliminates the wet granulation step, saving time and energy.
- High purity. The product meets the strict requirements of pharmacopoeias, as confirmed by the microcrystalline cellulose instructions and specification (COA).
Applications. What is cellulose used for?
The range of raw material applications is vast. Let's take a closer look at the applications of microcrystalline cellulose in various industries:
1. Pharmaceuticals and Dietary Supplements
The main answer to the question "What is microcrystalline cellulose used for?" lies in tablet production. It functions as:
- A filler to create volume.
- A binder to strengthen the tablet (dry binder).
- A disintegrant (disintegrant) to ensure rapid dissolution of the medication in the stomach.
2. Food Industry and Dietetics
Microcrystalline cellulose E460 is widely known as an additive that prevents caking and clumping. But it has gained particular popularity in the field of healthy nutrition.
- Microcrystalline cellulose for weight loss is used as a source of dietary fiber. It's low in calories and creates a feeling of fullness.
- Microcrystalline cellulose cleansing is a popular trend. Acting as an absorbent, it mechanically cleanses the intestines (consumers often search for microcrystalline cellulose for weight loss reviews confirming this effect).
- If you're looking for where to buy an ingredient for making low-calorie mayonnaise or ice cream, MCC 112 will provide the right texture.
3. Cosmetics and Household Chemicals
Microcrystalline cellulose in cosmetics replaces polyethylene exfoliating particles. It is biodegradable and safe.
- Microcrystalline cellulose for soap makers is sought after in Ukraine and other countries by those who make gentle peels and scrubs.
- It is used as a filler in dry shampoos and powders.
Commercial information. How to Buy and Price
If your production requires microcrystalline cellulose, it's best to purchase it from a direct wholesale supplier to guarantee quality and certification.
- Microcrystalline cellulose price: The cost depends on the batch size. Microcrystalline cellulose price in UAH (converted at the exchange rate) or in another currency is available upon request.
- Buy microcrystalline cellulose wholesale: We supply raw materials in 20-25 kg bags. This is the optimal packaging for production lines.
- Microcrystalline cellulose kg price: To calculate the exact cost of a batch, taking logistics into account, please contact the sales department.
We work with clients throughout the region. Interested in microcrystalline cellulose in Kyiv, microcrystalline cellulose in Kharkiv, or microcrystalline cellulose powder in Odessa? We offer delivery to any city (contact our manager for details). Also, if you'd like to purchase microcrystalline cellulose in Ukraine with a full package of documents, our product is the ideal solution. You can order microcrystalline cellulose right now using the form on our website. Storage Conditions and Safety What is microcrystalline cellulose in terms of storage? This is a hygroscopic product.
- Important: MCC 112 actively absorbs moisture from the air. Store only in tightly sealed original packaging.
- Microcrystalline cellulose, which you can buy from us, has a long shelf life (re-test date) when stored properly.
- The product is safe and non-toxic (how to take pure microcrystalline cellulose is indicated in the instructions for the finished dietary supplements; we supply the raw materials for production).
To receive a Certificate of Analysis (COA) and a commercial offer, please click the "Get a price" button.